Weight Loss

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How do weight loss medications work? Some are designed to make you feel full more quickly and stay full longer, while others reduce your appetite and curb cravings. GLP-1 (glucagon-like peptide 1) agonists are well-known for their effectiveness not only with diabetes management, but also weight loss. GLP-1 agonists stimulate the receptor for the hormone glucagon-like peptide 1, which increases insulin production and satiety (or feelings of fullness). “A GLP-1 agonist releases in the gastrointestinal tract after a meal and travels to the hunger center of the brain, telling us we’re full,” explains Dr. Lent. “It will also slow down the movement of food though the stomach, a mechanism known as delayed gastric emptying, which makes us feel full longer.” GLP-1 agonists currently approved for weight loss include liraglutide and certain commercial labels of semaglutide. Semaglutide, in lower doses, is also used for diabetes treatment; you may see dulaglutide used for diabetes as well. The newest diabetes medication, tirzepatide, on the other hand, triggers two receptors, GLP-1 and glucose-dependent insulin tropic polypeptide (GIP), giving it a possible advantage. Studies have shown that tirzepatide is roughly twice as effective as semaglutide but is not yet indicated for weight loss – though many experts expect that to change. Other types of medications, such as phentermine/topiramate and naltrexone/bupropion, work differently to promote weight loss. How these work as appetite suppressants isn't entirely clear, but they are effective at controlling hunger and diminishing food cravings, according to Dr. Lent. It varies based on which drug you take. GLP-1s typically promote more weight loss – around 10%-15% of your current body weight. With other appetite suppressants, people lose an average.